Synergistic Effects of Galantamine and Memantine in Attenuating Scopolamine-Induced Amnesia in Mice

Synergistic Effects of Galantamine and Memantine in Attenuating Scopolamine-Induced Amnesia in Mice

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We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model in mice.We evaluated the effects of the two drugs, either alone or in combination, using the spontaneous 730 sunken lake road alternation and object recognition tasks.In both tests, combination of low doses of galantamine (0.

1 mg/kg, s.c.) and memantine (0.

5 mg/kg, i.p.), which were sub-active per se, rescued the memory impairment kenya tree coral for sale induced by scopolamine (1 mg/kg, i.

p.).The results suggest that combinations of galantamine and memantine might provide a more effective treatment of memory impairments in cognitive disorders than either drug used alone.

Keywords:: neurodegenerative disease, multi-target, memory impairment.